Loading...
Please wait, while we are loading the content...
Similar Documents
Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Yildiz, Fahrettin M. Çoban, Sacit Terzi, Alpaslan Ateş, Mustafa Aksoy, Nurten Cakir, Hale Ocak, Ali Riza Bitiren, Muharrem |
| Copyright Year | 2008 |
| Abstract | AIM To determine whether Nigella sativa prevents hepatic ischemia-reperfusion injury to the liver. METHODS Thirty rats were divided into three groups as sham (Group 1), control (Group 2), and Nigella sativa (NS) treatment group (Group 3). All rats underwent hepatic ischemia for 45 min followed by 60 min period of reperfusion. Rats were intraperitoneally infused with only 0.9% saline solution in group 2. Rats in group 3 received NS (0.2 mL/kg) intraperitoneally, before ischemia and before reperfusion. Blood samples and liver tissues were harvested from the rats, and then the rats were sacrificed. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) levels were determined. Total antioxidant capacity (TAC), catalase (CAT), total oxidative status (TOS), oxidative stress index (OSI) and myeloperoxidase (MPO) in hepatic tissue were measured. Also liver tissue histopathology was evaluated by light microscopy. RESULTS The levels of liver enzymes in group 3 were significantly lower than those in the group 2. TAC in liver tissue was significantly higher in group 3 than in group 2. TOS, OSI and MPO in hepatic tissue were significantly lower in group 3 than the group 2. Histological tissue damage was milder in the NS treatment group than that in the control group. CONCLUSION Our results suggest that Nigella sativa treatment protects the rat liver against to hepatic ischemia-reperfusion injury. |
| Starting Page | 17 |
| Ending Page | 23 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.zentrum-der-gesundheit.de/pdf/schwarzkuemmeloel-ia_04.pdf |
| PubMed reference number | 18777598v1 |
| Volume Number | 14 |
| Issue Number | 33 |
| Journal | World journal of gastroenterology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Alanine Antioxidants Aspartate Transaminase Aspartic Acid CATALASE Histopathology Lactate Dehydrogenase Lactic acid Light Microscopy Liver diseases Liver parenchyma Nigella (plant) Nigella sativa Oxidative Stress Peroxidase Reperfusion Injury Reperfusion Therapy Saline Solution Soft Tissue Injuries Thoracic Outlet Syndrome Transaminases hepatic ischemia |
| Content Type | Text |
| Resource Type | Article |
