Poly(N-vinylpyrrolidone-b-(γ-benzyl-L-glutamate)) – synthesis and self-assembly into pH-sensitive micelles

Content Provider	Semantic Scholar
Author	Jacobs, Jaco Lana, Gwenaelle Pound‐ Klumperman, Bert
Copyright Year	2012
Abstract	The synthesis of hybrid amphiphilic block copolymers using thiazolidine chemistry is described. The system consists of poly(N-vinylpyrrolidone) (PVP) as the hydrophilic polymer while incorporating a hydrophobic polypeptide, poly(γ-benzyl-L-glutamate) (PBLG), resulting in a pH-sensitive bioconjugate. A modular approach was used for the synthesis of the conjugates. As a first step, the synthesis of well-defined end-functional polymers is described. An optimized procedure was developed to quantitatively obtain ω-aldehyde end-functional PVP as well as one to synthesize cysteine end-functional PBLG. The latter makes use of a modified deprotection step for the thiol-protecting acetamidomethyl group. The self-assembly behaviour and pH dependence of the PVP-PBLG bioconjugate is demonstrated, which indicates the potential of this system as a “smart” drug delivery vehicle.
Starting Page	2551
Ending Page	2560
Page Count	10
File Format	PDF HTM / HTML
DOI	10.1039/C2PY20339A
Alternate Webpage(s)	http://www.rsc.org/suppdata/py/c2/c2py20339a/c2py20339a.pdf
Alternate Webpage(s)	https://doi.org/10.1039/C2PY20339A
Volume Number	3
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article