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Can Ultrafiltration be Used as Primary Treatment of Congestive Heart Failure
| Content Provider | Semantic Scholar |
|---|---|
| Author | Tallis, Jennifer |
| Copyright Year | 2011 |
| Abstract | Objective: To determine whether ultrafiltration can be used as primary treatment of Congestive Heart Failure. Study Design: Review of three English language, non-blinded randomized controlled trials from 2005, 2007 and 2008. Data Sources: Randomized, controlled, non-blinded clinical trials comparing ultrafiltration to intravenous diuretics found using Ovid Medline and PubMed databases. Outcome measured: Weight loss after 48 hours was measured at discharge, and at days 10, 30, and 90 post-discharge. Dyspnea after 48 hours was measured as a perception of the patient on a scale from 1 to 7, 1 being markedly worse, 7 being marked improvement. Net fluid loss after 48 hours was measured as ultrafiltrated in the ultrafiltration group and as urine output in the intravenous diuretic and usual care groups. Finally, rehospitalizations for heart failure-related issues was measured, starting on the day of discharge through 90 days post-discharge. Results: There were statistically significant results for weight loss during hospitalization, and the p-value for rehospitalization for symptoms of heart failure 90 days post-treatment was < 0.05. Net fluid loss over 48 hours was didn’t prove to be significant. Hypotension was the most frequent adverse event reported, but was not reported consistently throughout all three studies; one study didn’t report adverse events at all. Conclusions: The studies have proven ultrafiltration to be a safe alternative to intravenous diuretics for the treatment of congestive heart failure but there is not enough consistent, significant data to say that it can be used as initial primary treatment. Further studies with larger and more specific sample populations need to be done in order to better prove true long-term efficacy and cost-effectiveness. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://digitalcommons.pcom.edu/cgi/viewcontent.cgi?article=1045&context=pa_systematic_reviews&httpsredir=1&referer= |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
