NDLI: Dalmanol biosyntheses require coupling of two separate polyketide gene clusters† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc03697g

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Dalmanol biosyntheses require coupling of two separate polyketide gene clusters† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc03697g

Content Provider	Semantic Scholar
Author	Zhou, Z. Z. Lin, Li Ping Zhang, X. Ge, Hui Ming Jiao, Rui Hua Tan, Ren Xiang
Copyright Year	2019
Abstract	Polyketide-polyketide hybrids are unique natural products with promising bioactivity, but the hybridization processes remain poorly understood. Herein, we present that the biosynthetic pathways of two immunosuppressants, dalmanol A and acetodalmanol A, result from an unspecific monooxygenase triggered hybridization of two distinct polyketide (naphthalene and chromane) biosynthetic gene clusters. The orchestration of the functional dimorphism of the polyketide synthase (ChrA) ketoreductase (KR) domain (shortened as ChrA KR) with that of the KR partner (ChrB) in the bioassembly line increases the polyketide diversity and allows the fungal generation of plant chromanes (e.g., noreugenin) and phloroglucinols (e.g., 2,4,6-trihydroxyacetophenone). The simultaneous fungal biosynthesis of 1,3,6,8- and 2-acetyl-1,3,6,8-tetrahydroxynaphthalenes was addressed as well. Collectively, the work may symbolize a movement in understanding the multiple-gene-cluster involved natural product biosynthesis, and highlights the possible fungal generations of some chromane- and phloroglucinol-based phytochemicals.
Starting Page	73
Ending Page	82
Page Count	10
File Format	PDF HTM / HTML
DOI	10.1039/c8sc03697g
PubMed reference number	30746075
Journal	Medline
Volume Number	10
Alternate Webpage(s)	https://pubs.rsc.org/en/content/articlepdf/2019/sc/c8sc03697g?page=search
Alternate Webpage(s)	http://www.rsc.org/suppdata/c8/sc/c8sc03697g/c8sc03697g1.pdf
Alternate Webpage(s)	https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e0/97/SC-010-C8SC03697G.PMC6335865.pdf
Alternate Webpage(s)	https://doi.org/10.1039/c8sc03697g
Journal	Chemical science
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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