NDLI: Spironolactone Plus Full-Dose ACE Inhibition in Patients with Idiopathic Membranous Nephropathy and Nephrotic Syndrome: Does It Really Work?

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Spironolactone Plus Full-Dose ACE Inhibition in Patients with Idiopathic Membranous Nephropathy and Nephrotic Syndrome: Does It Really Work?

Content Provider	Semantic Scholar
Author	Cravedi, Paolo Brusegan, Varusca Ruggenenti, Piero Campbell, Ruth C. Remuzzi, Giuseppe
Copyright Year	2010
Abstract	We have studied the effects of add-on spironolactone treatment (100 mg/day) in 11 patients with idiopathic membranous nephropathy (IMN) and > 3 gm proteinuria/day despite angiotensin converting enzyme (ACE) inhibitor therapy titrated to a systolic/diastolic blood pressure < 120/80 mmHg. Blood pressure, 24-hour urinary protein excretion, and creatinine clearance were measured prior to, after two months of combined therapy, and after a 2-month withdrawal period of spironolactone. While systolic and diastolic blood pressure decreased significantly after spironolactone therapy, proteinuria did not improve. Serum potassium increased significantly as well, with three patients requiring resin-binding therapy. Thus, spironolactone seems to have no additional antiproteinuric effects over ACE inhibitor therapy in patients with IMN and nephrotic syndrome and carries the risk of significant hyperkalemia.
Starting Page	1
Ending Page	9
Page Count	9
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.mdpi.com/1424-8247/3/1/1/pdf
PubMed reference number	27713239v1
Volume Number	3
Journal	Pharmaceuticals
Language	English
Access Restriction	Open
Subject Keyword	Angiotensin-Converting Enzyme Inhibitors Angiotensins Creatinine clearance measurement Diastole Idiopathic Membranous Glomerulonephritis Kidney Diseases Nephrotic Syndrome Patients Peptidyl-Dipeptidase A Potassium Resins, Plant Spironolactone Tissue membrane torr
Content Type	Text
Resource Type	Article

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