Calcitonin gene-related peptide enhances calcium current of rat dorsal root ganglion neurons and spinal excitatory synaptic transmission

Content Provider	Semantic Scholar
Author	Ryu, Pan Dong Gerber, Gábor Murase, Kazuyuki Randić, Mirjana
Copyright Year	1988
Abstract	The actions of calcitonin gene-related peptide (CGRP) were examined on Ca2+-dependent action potentials and voltage-dependent Ca2+ currents in rat dorsal root ganglion (DRG) neurons in vitro. In addition, we tested the effect of CGRP on excitatory synaptic transmission in the rat spinal dorsal horn. CGRP produced a reversible increase in the amplitude and the duration of the Ca2+ spike of DRG neurons and directly increased the voltage-dependent Ca2+ current by enhancing both the transient and the sustained components of the current. The increase in the Ca2+ current is likely to be responsible for the increase in the Ca2+ spike and facilitation of excitatory synaptic transmission.
Starting Page	305
Ending Page	312
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1016/0304-3940(88)90544-7
PubMed reference number	2843797
Journal	Medline
Volume Number	89
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/0304394088905447
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/0304394088905447?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0304-3940%2888%2990544-7
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article