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Bilirubin as a cerebrospinal fluid marker of sentinel subarachnoid hemorrhage: a preliminary report in pigs.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Morgan, Chad J. Pyne-Geithman, Gail J. Jauch, Edward C. Shukla, Rakesh Wagner, Kenneth R. Clark, J. F. Zuccarello, Mario |
| Copyright Year | 2004 |
| Abstract | OBJECT A model of subarachnoid hemorrhage (SAH) in pigs was developed to investigate bilirubin concentration in cerebrospinal fluid (CSF) as a potential marker of sentinel SAH. METHODS Seven male Yorkshire pigs received a 250-microl injection of either whole autologous arterial blood (four animals) or isotonic saline (three animals) into the cisternae magna in an effort to produce volumetrically a model of sentinel SAH and a control injection model, respectively. Cerebrospinal fluid volumes of 100 microl were then collected from both the lumbar cistern and cisternae magna at 1 to 2-hour intervals for a total of 24 hours postinjection. The CSF was then tested for bilirubin. Mean concentrations of bilirubin (+/- standard deviation [SD]) obtained from the lumbar cistern 24 hours following the injection of blood or saline were 4.38 +/- 1.04 microM in the SAH animals and 1.02 +/- 0.05 microM in the controls. At 24 hours postinjection, mean concentrations (+/- SD) of cisternae magna bilirubin were 7.29 +/- 1.33 microM and 1.33 +/- 0.14 microM in the SAH animals and controls, respectively. In the SAH group, both the lumbar cistern and cisternae magna bilirubin concentrations differed significantly from baseline values 12 hours following SAH. CONCLUSIONS Elevated concentrations of CSF bilirubin can be detected following a low-volume SAH, and the production of bilirubin occurred over a predictable time course. Twelve hours after hemorrhage, an elevated CSF bilirubin concentration was an indicator of hemolysis occurring in the subarachnoid spaces. The presence of bilirubin in CSF is a potential marker for differentiating SAHs from traumatic lumbar punctures in humans. |
| Starting Page | 2946 |
| Ending Page | 2955 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://thejns.org/downloadpdf/journals/j-neurosurg/101/6/article-p1026.pdf |
| PubMed reference number | 15597764v1 |
| Volume Number | 101 |
| Issue Number | 6 |
| Journal | Journal of neurosurgery |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Bilirubin Cerebrospinal Fluid Coxa Magna Headache Hemolysis (disorder) Patients Physiological Sexual Disorders Puncture wound S-Adenosylhomocysteine Sleep Apnea, Obstructive Spinal Puncture Subarachnoid Hemorrhage Subarachnoid Space X-Ray Computed Tomography |
| Content Type | Text |
| Resource Type | Report |
