Olive oil preparation determines the atherosclerotic protection in apolipoprotein E knockout mice.

Content Provider	Semantic Scholar
Author	Acín, Sergio Navarro, Maria Angeles Rodríguez Perona, Javier Sanchez Arbones-Mainar, José Miguel Surra, Joaquín Carlos Guzmán, Mario Arceo Carnicer, Ricardo Arnal, Carmen Orman, Israel Segovia, José C. Osada, Jesús Ruíz-Gutiérrez, Valentina
Copyright Year	2007
Abstract	Oils enriched in monounsaturated fatty acids do not seem to behave similarly in protecting against the development of atherosclerosis in animal models, which has been attributed to the presence of soluble phenolic compounds. To test the relevance of other components of oils in the prevention of atherosclerosis, two olive oils from the same cultivar devoid of soluble phenolic compounds were prepared using different procedures (pressure or centrifugation), characterized and fed to apolipoprotein E-deficient mice as 10% (w/w) of their diet. The 2 olive oils had similar levels of monounsaturated fatty acids and squalene, but they differed in their content of linoleic, phytosterols, tocopherols, triterpenes and waxes, which were particularly enriched in the test olive oil obtained by centrifugation. In mice that received a diet enriched in the olive oil derived through centrifugation, the progression of atherosclerosis was delayed compared to the mice that received standard olive oil. That effect was associated with decreases in plasma triglycerides, total and non-high-density lipoprotein cholesterol and isoprostane 8-iso-prostaglandin F(2alpha). Our results clearly indicate that the preparation of olive oil is crucial in determining its antiatherosclerotic effect, which extends beyond the presence of phenolic compounds. The test olive oil exerted its antiatherosclerotic effects by modifying plasma lipids and oxidative stress, and it might be a good candidate to replace other fats in functional foods.
Starting Page	1250
Ending Page	1254
Page Count	5
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.unav.es/preventiva/predimed/articulos/J%20Nutr%20Biochem.%202007-18-418-24.pdf
PubMed reference number	17049830v1
Volume Number	18
Issue Number	6
Journal	The Journal of nutritional biochemistry
Language	English
Access Restriction	Open
Subject Keyword	Animal Model Apolipoprotein E Apolipoproteins Atherosclerosis C10orf90 gene Centrifugation Cholesterol Fatty Acids Fatty Acids, Monounsaturated Functional Food Isoprostanes Lipids Lipoproteins Oxidative Stress Percent Mass per Mass Phytosterols Prostaglandin-Endoperoxide Synthase Prostaglandins Squalene Tocopherols Triglycerides Triterpenes Waxes olive oil physical hard work
Content Type	Text
Resource Type	Article