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Tailoring immunoglobulin Fc for highly potent and serum-stable therapeutic antibodies
| Content Provider | Semantic Scholar |
|---|---|
| Author | Jung, Sang Taek |
| Copyright Year | 2013 |
| Abstract | Antibody Fc region, a recruiter and a frontline commander in the combat against cancer and infectious pathogens, mediates potent immune effector functions by engaging Fc receptors and serum complement proteins. Recent studies indicate that the Fc region is particularly amenable to modifications that enhance potency and serum stability through amino acid substitution and glycan modification. In order to modulate the interaction of the Fc domain with Fc-binding ligands (FcγRs, C1q, and FcRn), various engineering strategies have been employed; these studies are discussed in this review. |
| Starting Page | 625 |
| Ending Page | 636 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/s12257-012-0711-0 |
| Volume Number | 18 |
| Alternate Webpage(s) | https://page-one.live.cf.public.springer.com/pdf/preview/10.1007/s12257-012-0711-0 |
| Alternate Webpage(s) | https://doi.org/10.1007/s12257-012-0711-0 |
| Journal | Biotechnology and Bioprocess Engineering |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
