Effects of postsynaptic depolarization in the induction of synaptic depression between a granule cell and a Purkinje cell in rat cerebellar culture

Content Provider	Semantic Scholar
Author	Hirano, Tomoo
Copyright Year	1990
Abstract	In a previous paper it has been reported that the repetitive conjunctive stimulation of both a granule cell and an inferior-olivary neuron depresses the synaptic transmission between a cerebellar granule cell and a Purkinje cell, and the repetitive stimulation of only a granule cell potentiates the transmission in a simple culture preparation. This paper demonstrates, by experiments controlling the membrane potential of a postsynaptic Purkinje cell, that the postsynaptic depolarization of a Purkinje cell during activation of a granule cell is both necessary and sufficient to induce the depression, and that the potentiation is induced without the postsynaptic depolarization.
Starting Page	145
Ending Page	147
Page Count	3
File Format	PDF HTM / HTML
DOI	10.1016/0304-3940(90)90819-U
PubMed reference number	2280885
Journal	Medline
Volume Number	119
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/030439409090819U
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/030439409090819U?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0304-3940%2890%2990819-U
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article