NDLI: Predictors of mortality in patients with acute myocardial infarction and cardiogenic shock.

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Predictors of mortality in patients with acute myocardial infarction and cardiogenic shock.

Content Provider	Semantic Scholar
Author	Katayama, Toshiro Nakashima, Hiroshi Takagi, Chisa Honda, Yukiharu Suzuki, Shin Ichiro Yano, Katsusuke
Copyright Year	2005
Abstract	BACKGROUND Although cardiogenic shock (CS) is the leading cause of death for acute myocardial infarction (AMI) patients, reliable predictive factors in the acute stage, such as cardiovascular peptides, have not yet been identified. METHODS AND RESULTS In 42 consecutive AMI patients with CS on admission, successfully treated by primary percutaneous coronary intervention (PCI) within 12 h of onset, related factors including brain natriuretic peptide (BNP), atrial natriuretic peptide (ANP), renin, aldosterone, catecholamines, and adrenomedullin, were investigated 24 h from onset, as well as the 1-year mortality rates. During the 12-month follow-up period, 15 patients died from cardiovascular causes (group D). There were no significant differences in patient characteristics, angiographic findings, and left ventricular systolic function between group D subjects and the survivors (group S: n=27). Multivariate analysis identified high levels of adrenomedullin as an independent predictor of 1-year mortality (risk ratio: 6.42, 95% confidence interval, 1.49-43.31, p<0.05). CONCLUSIONS The acute-phase plasma concentration of adrenomedullin may be a reliable predictor of mortality in patients with AMI complicated by CS and successfully treated by direct PCI, as may be BNP concentration, peak-creatine kinase value, and ventricular fibrillation.
Starting Page	3214
Ending Page	3216
Page Count	3
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.jstage.jst.go.jp/article/circj/69/1/69_1_83/_pdf
PubMed reference number	15635209v1
Volume Number	69
Issue Number	1
Journal	Circulation journal : official journal of the Japanese Circulation Society
Language	English
Access Restriction	Open
Subject Keyword	ADM gene Acute myocardial infarction Aldosterone Atrial Natriuretic Factor Catecholamines Cessation of life Confidence Intervals Creatine Kinase Heart Atrium Nesiritide Patients Percutaneous Coronary Intervention Shock, Cardiogenic Survivors Ventricular Fibrillation adrenomedullin
Content Type	Text
Resource Type	Article

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