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Suppression of methionine-induced hyperhomocysteinemia by dietary eritadenine in rats.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sekiya, Atsushi Fukada, Shin-Ichiro Morita, Tatsuya Kawagishi, Hirokazu Sugiyama, Kimio |
| Copyright Year | 2006 |
| Abstract | The effect of dietary eritadenine on the plasma homocysteine concentration was investigated in methionine-induced hyperhomocysteinemic rats. The rats were fed on the control or eritadenine-supplemented (50 mg/kg) diet for 10 d. The animals were then injected with saline or methionine at a level of 100 or 300 mg/kg of body weight, and sacrificed 2 h or a more appropriate time after injection. The methionine injection increased the post-2 h concentration of plasma homocysteine in a dose-dependent manner in the control rats, this increase being significantly suppressed in the eritadenine-fed rats. This effect persisted up to 8 h after the methionine injection. The hepatic concentrations of S-adenosylmethionine and S-adenosylhomocysteine were increased by eritadenine, whereas the hepatic homocysteine concentration was inversely decreased. The cystathionine beta-synthase activity in the liver was increased by eritadenine. It is suggested from these results that eritadenine might suppress the methionine-induced increase in plasma homocysteine concentration by dual mechanisms: slowing the homocysteine production from S-adenosylhomocysteine and increasing the removal of homocysteine due to the enhanced activity of cystathionine beta-synthase. |
| Starting Page | 499 |
| Ending Page | 523 |
| Page Count | 25 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.jstage.jst.go.jp/article/bbb/70/8/70_60075/_pdf/-char/en |
| PubMed reference number | 16880595v1 |
| Volume Number | 70 |
| Issue Number | 8 |
| Journal | Bioscience, biotechnology, and biochemistry |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Dual Enhanced Biochemical Activity Hyperhomocysteinemia Methionine S-Adenosylhomocysteine S-Adenosylmethionine cystathionine beta-synthase activity eritadenine homocysteine mg/kg |
| Content Type | Text |
| Resource Type | Article |
