NDLI: 梔子中Geniposide 於大鼠之代謝動力學及其與西藥之交互作用; Metabolic Pharmacokinetics of Geniposide in Gardenia Fruits and Interactions with Western Medicines in Rats

Content Provider	Semantic Scholar
Author	賴姵妘 Lai, Pei-Yun
Copyright Year	2006
Abstract	Geniposide is an iridoid glycoside in the fruits of Gardenia jasminoides ELLIS. It has been reported that geniposide is transformed to genipin by intestinal bacteria in animals. We attempted to investigate the pharmacokinetics of geniposide in rat after oral administration of traditional decoction of Gardenia fruits (GF). The concentration of geniposide in the GF decoction was determined by HPLC method. In addition, the pharmacokinetics of genipin was investigated after intravenous and oral administrations. Based on the pharmacokinetic study, we proposed possible pharmacokintic interactions between GF decoction with methotrexate (MTX), phenytoin (PHT) and carbamazepine (CBZ), which are substrates of MRP2. Blood samples were withdrawn via cardiopuncture at specific time points after drug administration. Plasma samples were assayed by HPLC method prior to and after enzymatic hydrolysis with sulfatase and glucuronidase, respectively. Pharmacokinetic parameters were calculated using noncompartment model of WinNonlin. Our results indicated that after oral administration of GF decoction,
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://ir.cmu.edu.tw/ir/bitstream/310903500/929/1/cmu-95-9363016-1.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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