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Relationship between circulating IGF-1 levels and traumatic brain injury-induced hippocampal damage and cognitive dysfunction in immature rats
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ozdemir, Durgul Baykara, Basak Aksu, I. Kiray, M. Arda, Mehmet Nuri |
| Copyright Year | 2012 |
| Abstract | It is well known that traumatic brain injury (TBI) induces the cognitive dysfunction resulting from hippocampal damage. In the present study, we aimed to assess whether the circulating IGF-I levels are associated with cognition and hippocampal damage in 7-day-old rat pups subjected to contusion injury. Hippocampal damage was examined by cresyl violet staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. Spatial memory performance was assessed in the Morris water maze. Serum IGF-1 levels decreased in both early and late period of TBI. Decreased levels of serum IGF-1 were correlated with hippocampal neuron loss and spatial memory deficits. Circulating IGF-1 levels may be predictive of cognitive dysfunction resulted from hippocampal damage following traumatic injury in developing brain. Therapy strategies that increase circulating IGF-1 may be highly promising for preventing the unfavorable outcomes of traumatic damage in young children. |
| Starting Page | 84 |
| Ending Page | 89 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.neulet.2011.11.059 |
| PubMed reference number | 22172933 |
| Journal | Medline |
| Volume Number | 507 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0304394011015813 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0304394011015813?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/j.neulet.2011.11.059 |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
