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Green tea extract and its major polyphenol (-)-epigallocatechin gallate improve muscle function in a mouse model for Duchenne muscular dystrophy.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Dorchies, Olivier M. Wagner, Stéphanie Vuadens, Ophélie Waldhauser, Katri Maria Bütler, T. Martin Kucera, Pavel Ruegg, Urs T. |
| Copyright Year | 2006 |
| Abstract | Duchenne muscular dystrophy is a frequent muscular disorder caused by mutations in the gene encoding dystrophin, a cytoskeletal protein that contributes to the stabilization of muscle fiber membrane during muscle activity. Affected individuals show progressive muscle wasting that generally causes death by age 30. In this study, the dystrophic mdx(5Cv) mouse model was used to investigate the effects of green tea extract, its major component (-)-epigallocatechin gallate, and pentoxifylline on dystrophic muscle quality and function. Three-week-old mdx(5Cv) mice were fed for either 1 or 5 wk a control chow or a chow containing the test substances. Histological examination showed a delay in necrosis of the extensor digitorum longus muscle in treated mice. Mechanical properties of triceps surae muscles were recorded while the mice were under deep anesthesia. Phasic and tetanic tensions of treated mice were increased, reaching values close to those of normal mice. The phasic-to-tetanic tension ratio was corrected. Finally, muscles from treated mice exhibited 30-50% more residual force in a fatigue assay. These results demonstrate that diet supplementation of dystrophic mdx(5Cv) mice with green tea extract or (-)-epigallocatechin gallate protected muscle against the first massive wave of necrosis and stimulated muscle adaptation toward a stronger and more resistant phenotype. |
| Starting Page | 89 |
| Ending Page | 95 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://ajpcell.physiology.org/content/ajpcell/290/2/C616.full.pdf |
| Alternate Webpage(s) | http://ajpcell.physiology.org/content/ajpcell/290/2/c616.full.pdf |
| PubMed reference number | 16403950v1 |
| Volume Number | 290 |
| Issue Number | 2 |
| Journal | American journal of physiology. Cell physiology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acclimatization Cessation of life Cytoskeleton DMD gene Epidermolysis Bullosa Dystrophica Fatigue Green Tea Extract Muscle Fibers Muscular Atrophy Muscular Dystrophy Muscular Dystrophy, Duchenne Mutation Myalgia Myopathy Necrosis Pentoxifylline Structure of extensor digitorum longus muscle of foot Tension Tetany Tissue membrane Triceps brachii muscle structure Triceps surae muscle structure chow chow epigallocatechin gallate polyphenols |
| Content Type | Text |
| Resource Type | Article |
