NDLI: Retinoid acid receptors in human colorectal cancer: An unexpected link with patient outcome.

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Retinoid acid receptors in human colorectal cancer: An unexpected link with patient outcome.

Content Provider	Semantic Scholar
Author	Perraud, Aurélie Nouaille, Michelle Akil, Hussein Petit, Daniel Labrousse, François J. Jauberteau, Marie-Odile Mathonnet, Muriel
Copyright Year	2011
Abstract	The status of the three retinoic acid receptors (RARs) α, β and γ in human colorectal cancer (CRC) has not as yet been examined. RARs are in part responsible for the actions of the retinoids (vitamin A and its derivatives), which are essential for human health and survival due to their extensive involvement in numerous cellular processes, in particular in epithelial morphology. The present study examined the expression of the three RARs in CRC using immunohistochemical analysis of paraffin-embedded tissue sections. RAR expression in tumor (T) and adjacent non-tumor (NT) specimens from stage I (n=6), stage II (n=34), stage III (n=26) and stage IV (n=14) CRC patients was compared with that in normal mucous membranes (n=10) from control individuals. The findings were correlated with tumor grade, treatment response (progression during treatment, remission, chemoresistance) and survival as clinicopathological parameters. RARα and γ expression was decreased with CRC stage in the T tissues (P=0.016 and P=0.052, respectively), suggesting that they may be used as predictive markers. RARβ expression in the NT tissues was associated with a more favorable prognosis (P=0.04). These results provide important information on the tumor microenvironment (the area adjacent to tumor cells).
Starting Page	491
Ending Page	497
Page Count	7
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://prodinra.inra.fr/ft?id=E74CAD7F-B11C-4854-B82D-9D76A0126B7E
Alternate Webpage(s)	https://www.spandidos-publications.com/etm/2/3/491/download
PubMed reference number	22977530v1
Volume Number	2
Issue Number	3
Journal	Experimental and therapeutic medicine
Language	English
Access Restriction	Open
Subject Keyword	Body tissue Colorectal Carcinoma Embedding Mucous Membrane Neoplasms Nephroblastoma Non-Small Cell Lung Carcinoma Patients Refractory anemia with ringed sideroblasts Retinoic Acid Receptor Retinoids Specimen Thioctic Acid Tretinoin Vitamin A Drug Class stage IV childhood Hodgkin's lymphoma
Content Type	Text
Resource Type	Article

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