NDLI: Potential mechanisms of neuroprotection induced by low dose total-body γ-irradiation in C57 mice administered with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

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Potential mechanisms of neuroprotection induced by low dose total-body γ-irradiation in C57 mice administered with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

Content Provider	Semantic Scholar
Author	Zhang, Yanling Li, Shurong Liang, Yajie Su, Bingyin
Copyright Year	2009
Abstract	Low dose total-body gamma-irradiation (TBI) was reported to confer neuroprotection against MPTP-induced dopaminergic neurotoxicity. After being pretreated with a single low dose (0.5Gy, 2.0Gy or 3.5Gy) TBI, C57BL/6 mice were administered with MPTP (15mg/kg, four times, 2h apart) intraperitoneally (i.p.). In the group pretreated with 2.0Gy TBI, with lower lymphocytes number, neuroprotection was found by High Performance Liquid Chromatography (HPLC) determination of the striatal dopamine. Contrarily, in the group pretreated with 0.5Gy TBI, with higher lymphocytes number, dopaminergic neuron toxicity was enhanced. So it was probably the decrease of lymphocytes, not the radiation hormesis that rendered the potential neuroprotection. And it was the balance between radiation injury and lymphocytopenia neuroprotection that decided the effect of low dose gamma-irradiation on MPTP-induced dopaminergic neurotoxicity.
Starting Page	106
Ending Page	110
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1016/j.neulet.2008.11.040
Alternate Webpage(s)	http://depart.xnyy.cn/upfiles/sjnk20100512052707.pdf
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0304394008016121
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0304394008016121?dgcid=api_sd_search-api-endpoint
PubMed reference number	19041369
Alternate Webpage(s)	https://doi.org/10.1016/j.neulet.2008.11.040
Journal	Medline
Volume Number	450
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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