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Effects of alpha-glucosidase inhibitors on mouth to caecum transit time in humans.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ladas, Spiros D. Frydas, Aristides Papadopoulos, Andrew Raptis, Sotos A. |
| Copyright Year | 1992 |
| Abstract | The alpha-glucosidase inhibitors acarbose and miglitol have been successfully used to control postprandial hyperglycaemia in diabetics. They probably work by slowing carbohydrate digestion and absorption, but their effect on mouth to caecum transit time has not been studied. The effect acarbose (100 mg), miglitol (100 mg), and placebo on mouth to caecum transit time (380 kcal breakfast with 20 g of lactulose) was investigated in 18 normal volunteers using breath hydrogen analysis. Both miglitol and acarbose significantly increased breath hydrogen excretion (F2,34 = 6.31, p = 0.005) and shortened the mouth to caecum transit time (F2,34 = 3.49, p = 0.04) after breakfast compared with placebo. There was a significant negative correlation between breath hydrogen excretion and mouth to caecum transit time suggesting that with shorter transit times significantly more carbohydrates were spilled into the colon. These results indicate that alpha-glucosidase inhibitors accelerate mouth to caecum transit time by inducing carbohydrate malabsorption. |
| Starting Page | 1145 |
| Ending Page | 1155 |
| Page Count | 11 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://gut.bmj.com/content/gutjnl/33/9/1246.full.pdf |
| PubMed reference number | 1427379v1 |
| Volume Number | 33 |
| Issue Number | 9 |
| Journal | Gut |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acarbose Alpha-glucosidase Carbohydrate nutrients Carbohydrates Cecum Hyperglycemia Lactulose Malabsorption Syndrome Oral cavity Protein Digestion (research activity) Reactive hypoglycemia alpha Glucosidase Inhibitors [MoA] kilocalorie miglitol |
| Content Type | Text |
| Resource Type | Article |
