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Oncogene-induced senescence (OIS) is triggered by B-RafV600E in human hepatocytes
| Content Provider | Semantic Scholar |
|---|---|
| Author | Park, Tae Jun |
| Copyright Year | 2015 |
| Abstract | Hepatocellular carcinoma (HCC) is one of the common malignant tumors in the world. Hepatocarcinogenesis is a stepwise process in which multiple genes are altered. This process occurs via activation of oncogenes, inactivation of tumor suppressor genes, reactivation of developmental pathways and activation of growth factor and their cognitive receptors. We focused one of the signaling pathways, specifically the MAPK signaling pathway which is associated with cell growth, proliferation and migration in HCC. B-Raf mutation has been reported in 61% of melanoma, 53% of papillary thyroid cancer and 11.5% of colorectal cancer patients. In the case of hepatoma, 23% of B-RafV600E mutation was reported. In this study, we want to evaluate the BRafV600E function in hepatocarcinogenesis. The overexpression B-RafV600E caused cell growth arrest and showed senescence-associated beta-galactosidase (SA-β-gal) staining. Moreover, overexpression of B-RafV600E caused activation MAPK Kinases pathway and cell cycle arrest. Abstract |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://repository.ajou.ac.kr/bitstream/201003/11359/1/KSBMB1.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
