Propargyloxycarbonyl as a protecting group for the side chains of serine , threonine and tyrosine

Content Provider	Semantic Scholar
Author	Ramesh, Ramapanicker Kavita, De Gupta, Shipra Srinivasan Chandrasekaran
Copyright Year	2008
Abstract	Propargyloxycarbonyl group is used as a protecting group for the hydroxyl groups of serine, threonine and tyrosine. The propargyloxycarbonyl derivatives of these hydroxy amino acids are stable to acidic and basic reagents commonly employed in peptide synthesis. The deprotection of the O-Poc derivatives using tetrathiomolybdate does not affect commonly used protecting groups such as N-Boc, NCbz, N-Fmoc, methyl and benzyl esters. The diand tripeptides synthesized using O-Poc derivatives of serine, threonine and tyrosine are stable, isolable compounds and give the hydroxy peptides in good yields when treated with tetrathiomolybdate.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://eprints.iisc.ernet.in/26682/1/999.pdf
Language	English
Access Restriction	Open
Subject Keyword	Acids Amino Acid Metabolism, Inborn Errors Amino Acids, Branched-Chain Carnitine esters:SCnt:Pt:Tiss:Qn Esters Hydroxyl Radical N-tert-butyloxycarbonylnorleucyl-leucyl-phenylalanine Reagents Threonine Trifluoroacetic Acid Tyrosine hydroxyl group tert-Butyl Alcohol tetrathiomolybdate
Content Type	Text
Resource Type	Article