NDLI: Absence of a persistently elevated 37 kDa fos-related antigen and AP-1-like DNA-binding activity in the brains of kainic acid-treated fosB null mice.

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Absence of a persistently elevated 37 kDa fos-related antigen and AP-1-like DNA-binding activity in the brains of kainic acid-treated fosB null mice.

Content Provider	Semantic Scholar
Author	Mandelzys, Allan Gruda, M. A. Bravo, Ramiro H. Morgan, J. I.
Copyright Year	1997
Abstract	Chronic stimulation of the nervous system or acute administration of kainic acid results in a persistent increase in AP-1-like DNA-binding activity in the brain. However, the composition and function of these AP-1 complexes remain controversial. By comparing wild-type and fosB-null mice treated with kainic acid, we establish that the complexes comprise JunD in association with an approximately 37 kDa Delta-FosB species. Delta-FosB was expressed persistently in neurons in many areas of the CNS, even though fosB mRNA only increased transiently. This implies that the 37 kDa protein is very stable. fosB-/- mice are predisposed to seizures. Therefore, the chronic expression of Delta-FosB elicited by kainic acid seizures may be indicative of a compensatory/protective role in the pathophysiology of epilepsy.
Starting Page	491
Ending Page	497
Page Count	7
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.jneurosci.org/content/jneuro/17/14/5407.full.pdf
Alternate Webpage(s)	http://www.jneurosci.org/content/17/14/5407.full.pdf
PubMed reference number	9204924v1
Volume Number	17
Issue Number	14
Journal	The Journal of neuroscience : the official journal of the Society for Neuroscience
Language	English
Access Restriction	Open
Subject Keyword	Brain CNS disorder Delta aminolevulinate/Creatinine:SRto:24H:Urine:Qn Epilepsy Kainic Acid Null Value Seizures gamma-delta T-Cell Receptor
Content Type	Text
Resource Type	Article

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