黃連素抑制人類舌癌細胞株SCC-4生長的活體外和活體內的分子作用機轉之研究;Molecular mechanisms of growth inhibition on human tongue cancer SCC-4 cells by berberine：in vitro and in vivo

Content Provider	Semantic Scholar
Author	何永鑽 Ho, Yung-Tsuan
Copyright Year	2009
Abstract	There is increasing evidence that urokinase-type plasminogen activator (u-PA) and matrix metalloproteinases (MMPs) play an important role in cancer metastasis and angiogenesis. Inhibition of u-PA and MMPs could suppress migration and invasion of cancer cells. Berberine, one of the main constituents of the plant Rhizoma coptidis, is a type of isoquinoline alkaloid, reported to have anti-cancer effects in different human cancer cell lines. There is however, no available information on effects of berberine on migration and invasion of human tongue cancer cells. Here, we report that berberine inhibited migration and invasion of human SCC-4 tongue squamous carcinoma cells. This action was mediated by the p-JNK, p-ERK, p-p38, IjK and NF-jB signaling pathways resulting in inhibition of MMP-2 and -9 in human SCC-4 tongue squamous carcinoma cells. Our Western blowing analysis also showed that berberine inhibited the levels of urokinase-plasminogen activator (u-PA). These results suggest that berberine down-regulates u-PA, MMP-2 and -9 expressions in SCC-4 cells through the FAK, IKK and NF-jB mediated pathways and a novel function of berberine is to inhibit the invasive capacity of malignant cells. 2009 Elsevier Ireland Ltd. All rights reserved.
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Alternate Webpage(s)	http://ir.cmu.edu.tw/ir/bitstream/310903500/369/1/cmu-98-9451001-1.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article