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Human umbilical cord-derived mesenchymal stem cells ameliorate the enteropathy of food allergies in mice
| Content Provider | Semantic Scholar |
|---|---|
| Author | Yan, Nannan Xu, Jie Zhao, Chuanxiang Gao, Fengwei Zhou, Wenhui Xiao, Tengfei Zhou, Xiaoming Shao, Qixiang Xia, Sheng Miao |
| Copyright Year | 2018 |
| Abstract | Food allergy prevalence has steadily increased worldwide over the past decades and immunotherapeutic treatment strategies are gaining attention. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) exhibit similar immune regulatory properties to bone marrow-derived MSCs. hUC-MCSs can be prepared with fewer ethical constraints and are potential candidates for allergic disorder therapies. The current study aimed to investigate potential antiallergic properties of hUC-MSCs in mice with ovalbumin (OVA)-induced food allergy. Administration of hUC-MSCs cells intraperitoneally combined with oral gavage of the culture medium significantly alleviated OVA-induced diarrhea symptoms. Additionally, this treatment significantly decreased IgE levels and the percentage of T helper 2 cells in the blood, which were increased in mice with OVA-induced food allergy. The mRNA levels of the inflammatory cytokines interleukin-4 and tumor necrosis factor-α, and inflammatory cell infiltration in mouse colons were significantly decreased in hUC-MSCs-treated animals compared with mice with OVA-induced food allergy. Goblet cells were detected in colons of allergy-induced mice and their numbers were reduced following treatment with hUC-MSCs. In addition, treatment with hUC-MSCs reestablished the gut flora. The results revealed that hUC-MSCs may have a potential application in food allergy therapy. |
| Starting Page | 4445 |
| Ending Page | 4456 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.spandidos-publications.com/etm/16/6/4445/download |
| Alternate Webpage(s) | https://tessera.spandidos-publications.com/10.3892/etm.2018.6763/download |
| PubMed reference number | 30546392v1 |
| Alternate Webpage(s) | https://doi.org/10.3892/etm.2018.6763 |
| DOI | 10.3892/etm.2018.6763 |
| Journal | Experimental and therapeutic medicine |
| Volume Number | 16 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Food Allergy Hypersensitivity Mesenchymal Stem Cells Umbilical cord structure Umbilicus (Anatomy) |
| Content Type | Text |
| Resource Type | Article |
