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Pharmacologically distinct, pertussis toxin-resistant inward currents evoked by metabotropic glutamate receptor (mGluR) agonists in dorsolateral septal nucleus (DLSN) neurons.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zheng, Fang Gallagher, Joel |
| Copyright Year | 1995 |
| Abstract | We have reported previously that a selective metabotropic glutamate receptor (mGluR) agonist, (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD), caused a slow membrane depolarization in rat dorsolateral septal nucleus (DLSN) neurons. Using single electrode voltage-clamp recording methods, we now investigate the pharmacological properties of the receptor that mediates ACPD-induced membrane currents in DLSN neurons recorded from pertussis toxin (PTX)-treated rats. Two pharmacologically distinct inward currents, that is, the ACPD current and Qm current, have been identified based on their agonist preference and sensitivity to various antagonists. The ACPD current is blocked by L-2-amino-4-phosphonobutyric acid (L-AP4), but is insensitive to L-aspartic acid-beta-hydroxamate (L-AA beta H), (+)-alpha-methyl-4-carboxyphenylglycine (+)-MCPG), or L-2-amino-3-phosphonopropionic acid (L-AP3). The Qm current is blocked by L-AA beta H and (+)-MCPG, but is insensitive to L-AP3 or L-AP4. These two inward currents distribute differentially within subpopulations of DLSN neurons. The ACPD current is the only current observed in most DLSN "burster" neurons, while the Qm current is observed more frequently in DLSN "nonburster" neurons. The pharmacological profiles of these currents suggest that the Qm current is likely mediated by mGluR1 or mGluR5, while the ACPD current is mediated by receptors that are pharmacologically distinct from any of the currently cloned mGluRs. |
| Starting Page | 3765 |
| Ending Page | 3767 |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.jneurosci.org/content/jneuro/15/1/504.full.pdf |
| PubMed reference number | 7823158v1 |
| Volume Number | 15 |
| Issue Number | 1 |
| Part | 2 |
| Journal | The Journal of neuroscience : the official journal of the Society for Neuroscience |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | 1-amino-1,3-dicarboxycyclopentane Amino Acids Aspartic Acid Cell Nucleus Clone Cells Glutamate Receptor Glutamic Acid L-2-amino-4-phosphonobutyrate Neurons Pertussis Toxin Pharmacology RPL10 gene Receptors, Metabotropic Glutamate Thioctic Acid Tissue membrane beta Thalassemia cor tmc-ap3 protein, Hordeum vulgare d-alpha-Tocopheryl Acetate dorsal raphe nucleus membrane depolarization |
| Content Type | Text |
| Resource Type | Article |
