Fatty Acid Composition of Lipoprotein Lipids in Hepatobiliary Diseases 1 )

Content Provider	Semantic Scholar
Author	Migi, Maria Isabel Arranz Lasuncion, El Angel Perales, José Carlos Herrera, Emilio Lorenzo, Isabel Carcamo, Cristina Concostrina, Luis Villar, Juan José E. Gasalla, Rafael
Copyright Year	2009
Abstract	Liver damage and alterations in the exocrine function of the gland lead to a profound alteration of the plasma lipoprotein profile. To determine whether hepatic disease results in changes in the lipoprotein fatty acid composition, i. e. to determine whether liver function influences the homeostasis of complex lipids in plasma, we studied the fatty acid profile of lipids from VLDL, LDL and HDL, as well as from total plasma, in thirty-one patients of both sexes with hepatobiliary pathology (compensated liver cirrhosis, uncompensated liver cirrhosis, primary biliary cirrhosis, other intrahepatic cholestasis, and acute viral hepatitis). We also studied a group of healthy adults as controls. We present the lipoprotein profile and the fatty acid composition (myristic C14, palmitic C16, palmitoleic C16 : 1, stearic CIS, oleic CIS : 1, linoleic CIS : 2, eicosatrienoic C20 : 3co6 and arachidonic C20 : 4) of lipoprotein and total plasma triacylglycerols, cholesteryl esters and phospholipids. The main observation of this study is that, despite the profound changes in the lipoprotein profile and the lower abundance of polyunsaturated fatty acids in complex lipids, the composition of all triagylglycerols, cholesteryl esters and phospholipids is very similar for the corresponding lipoproteins of patients with hepatobiliary disease and of control subjects. This indicates that in the controls as in the studied patients, the exchange of lipids between plasmatic lipoproteins is very rapid and demonstrates the possible importance of the extrahepatic synthesis of cholesteryl ester transfer protein.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://edoc.hu-berlin.de/oa/degruyter/cclm.1996.34.9.701.pdf
Language	English
Access Restriction	Open
Subject Keyword	8,11,14-Eicosatrienoic Acid Arachidonic Acid Chemical and Drug Induced Liver Injury Cholesterol Esters Cisplatin Fatty Acids Fatty Liver Fibrosis Hardware description language Hematological Disease Hepatobiliary System Homeostasis Intrahepatic Cholestasis Lipids Lipoproteins Lipoproteins, IDL Liver Cirrhosis Liver diseases Myristic Acid Palmitic Acid Patients Phospholipids Plasma Active Primary biliary cirrhosis Thioctic Acid Triglycerides Very low density lipoprotein Viral hepatitis hepatobiliary disease palmitoleic acid
Content Type	Text
Resource Type	Article