NDLI: Mature Purkinje cells require the retinoic acid-related orphan receptor-α (RORα) to maintain climbing fiber mono-innervation and other adult characteristics.

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Mature Purkinje cells require the retinoic acid-related orphan receptor-α (RORα) to maintain climbing fiber mono-innervation and other adult characteristics.

Content Provider	Semantic Scholar
Author	Chen, Xiao Ru Heck, Nicolas Lohof, Ann M. Rochefort, Christelle Morel, Marie-Pierre Wehrlé, Rosine Doulazmi, Mohamed Marty, Serge Cannaya, Vidjeacoumary Avci, Hasan X. Mariani, Jean Rondi-Reig, Laure Vodjdani, Guilan Sherrard, Rachel M. Sotelo, Constantino Dusart, Isabelle
Copyright Year	2013
Abstract	Neuronal maturation during development is a multistep process regulated by transcription factors. The transcription factor RORα (retinoic acid-related orphan receptor α) is necessary for early Purkinje cell (PC) maturation but is also expressed throughout adulthood. To identify the role of RORα in mature PCs, we used Cre-lox mouse genetic tools in vivo that delete it specifically from PCs between postnatal days 10-21. Up to 14 d of age, differences between mutant and control PCs were not detectable: both were mono-innervated by climbing fibers (CFs) extending along their well-developed dendrites with spiny branchlets. By week 4, mutant mice were ataxic, some PCs had died, and remaining PC soma and dendrites were atrophic, with almost complete disappearance of spiny branchlets. The innervation pattern of surviving RORα-deleted PCs was abnormal with several immature characteristics. Notably, multiple functional CF innervation was reestablished on these mature PCs, simultaneously with the relocation of CF contacts to the PC soma and their stem dendrite. This morphological modification of CF contacts could be induced even later, using lentivirus-mediated depletion of rora from adult PCs. These data show that the late postnatal expression of RORα cell-autonomously regulates the maintenance of PC dendritic complexity, and the CF innervation status of the PC (dendritic vs somatic contacts, and mono-innervation vs multi-innervation). Thus, the differentiation state of adult neurons is under the control of transcription factors; and in their absence, adult neurons lose their mature characteristics and acquire some characteristics of an earlier developmental stage.
Starting Page	83
Ending Page	83
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.jneurosci.org/content/jneuro/33/22/9546.full.pdf
PubMed reference number	23719821v1
Alternate Webpage(s)	https://doi.org/10.1523/JNEUROSCI.2977-12.2013
DOI	10.1523/jneurosci.2977-12.2013
Journal	The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume Number	33
Issue Number	22
Language	English
Access Restriction	Open
Subject Keyword	Age related macular degeneration Atrophic Biologic Development Cell body of neuron Cessation of life Dendrites Diploid Cell Genus: Lentivirus group MERRF Syndrome Numerous Purkinje Cells RORA wt Allele Spiny Anteater TRANSCRIPTION FACTOR Tissue fiber Tretinoin ataxic calcium polycarbophil 625 MG Oral Tablet nerve supply
Content Type	Text
Resource Type	Article

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