Loading...
Please wait, while we are loading the content...
Similar Documents
Diarylheptanoids and flavonoids from viscum album inhibit LPS-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Nhiệm, Nguyễn Xuân Kiệm, Phan Văn Van, Minh Chau Kim, Nanyoung Park, Seon Ju Lee, Hwa Young Kim, Eun Sil Kim, Young Ho Kim, Sohyun Koh, Young-Sang Kim, Seung Hyun |
| Copyright Year | 2013 |
| Abstract | Three new diarylheptanoids, (3S,5R)-3-hydroxy-5-methoxy-1,7-bis(4-hydroxyphenyl)-6E-heptene (1), (3S,5S)-3-hydroxy-5-methoxy-1,7-bis(4-hydroxyphenyl)-6E-heptene (2), and (3S)-3-hydroxy-1,7-bis(4-hydroxyphenyl)-6E-hepten-5-one (3), four new flavonoid glycosides, 3,7,3'-tri-O-methylquercetin-4'-O-β-d-apiofuranosyl-(1→2)-O-β-d-glucopyranoside (4), 7,3'-di-O-methylquercetin-4'-O-β-d-glucopyranosyl-3-O-[6‴-(3-hydroxy-3-methylglutaroyl)]-α-d-glucopyranoside (5), 7,3'-di-O-methylquercetin-4'-O-β-d-glucopyranosyl-3-O-[(6'''''→5'''')-O-1'''''-(sinap-4-yl)-β-d-glucopyranosyl-6‴-(3-hydroxy-3-methylglutaroyl)]-α-d-glucopyranoside (6), and (2S)-5-hydroxy-7,3'-dimethoxyflavanone-4'-O-β-d-apiofuranosyl-(1→5)-O-β-d-apiofuranosyl-(1→2)-O-β-d-glucopyranoside (9), and 17 known compounds were isolated from the leaves and twigs of Viscum album. Compounds 1, 4, and 19 significantly inhibited LPS-stimulated production of TNF-α, IL-6, and IL-12p40 with IC50 values ranging from 0.09 ± 0.01 to 8.96 ± 0.45 μM. (+)-Medioresinol (13) showed inhibitory effects on LPS-stimulated production of IL-12p40 with an IC50 value of 2.00 ± 0.15 μM. |
| Starting Page | 495 |
| Ending Page | 502 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://isivast.org.vn:8888/bitstream/123456789/13817/1/Journal%20of%20Natural%20Products%2076%20(4)%20,%20pp.%20495-502,%202013.pdf |
| PubMed reference number | 23484668v1 |
| Alternate Webpage(s) | https://doi.org/10.1021/np300490v |
| DOI | 10.1021/np300490v |
| Journal | Journal of natural products |
| Volume Number | 76 |
| Issue Number | 4 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Bone Marrow Diarylheptanoids Flavonoids Glycosides Inhibitory Concentration 50 Interleukin-12 Subunit p40 Plant Leaves Viscum (genus) Viscum album cytokine ranimustine |
| Content Type | Text |
| Resource Type | Article |
