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Enantioseparation of Dansylated Amino Acids by Ligand-exchange Capillary Electrophoresis Using L-phenylalaninamide, L-lysine or L-threonine as Chiral Selector
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mohr, Stefan Dr Ing Hägele, Johannes S. Schmid, Martin G. |
| Copyright Year | 2011 |
| Abstract | In recent years enantioseparation of both active pharmaceutical ingredients and bio molecules such as amino acids became more and more necessary because in most cases the two stereo forms exhibit different pharmacological effects. This article deals with the chiral separation of dansylated amino acids by ligand-exchange capillary electrophoresis using L-phenylalaninamide, L-lysine and L-threonine as chiral selectors. Experiments with different central metal ions such as Cu(II), Co(II), Cd(II), Ni(II) and Zn(II) were carried out. Optimal conditions were found out by studying the effect of the pH and the selector molarity on the chiral resolution. Best separation was obtained for the Cu(II)/L-lysine complex, showing a chiral resolution up to 17 for Dns-DL-Met. (doi: 10.5562/cca1762) |
| Starting Page | 343 |
| Ending Page | 348 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.5562/cca1762 |
| Volume Number | 84 |
| Alternate Webpage(s) | http://hrcak.srce.hr/file/110999 |
| Alternate Webpage(s) | https://doi.org/10.5562/cca1762 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
