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Further Evidence of Association of OPRD1 & HTR1D Polymorphisms with Susceptibility to Anorexia Nervosa
| Content Provider | Semantic Scholar |
|---|---|
| Author | Brown, Kirsty M. Bujac, Sarah R. Mann, Evleen T. Campbell, David Alexander Blundell, John |
| Copyright Year | 2007 |
| Abstract | BACKGROUND A recent study reported strong evidence for the involvement of a region on human chromosome 1 and genetic susceptibility to anorexia nervosa (AN). A more detailed analysis of this region has suggested 2 genes that may account for this susceptibility. These data suggest that polymorphisms in both the serotonin 1D (HTR1D) and opioid delta 1 (OPRD1) receptor genes show a significant association with restricting AN (RAN). METHODS In the current study, we have conducted an independent association study on 226 females meeting DSM-IV criteria for AN and 678 matched volunteers. RESULTS We genotyped 4 SNPs in HTR1D and 6 SNPs in OPRD1. 3 SNPs were found to be associated with both RAN and binge-purge AN (BPAN) within the gene for OPRD1. We also found evidence of association between 2 polymorphisms within HTR1D and RAN. CONCLUSIONS These data support the hypothesis that polymorphisms within this region form a component of the genetic basis to susceptibility to RAN. However, further work is required to understand the processes that may be mediated by these genes. |
| Starting Page | 367 |
| Ending Page | 373 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.biopsych.2006.04.007 |
| PubMed reference number | 16806108 |
| Journal | Medline |
| Volume Number | 61 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S000632230600477X |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S000632230600477X?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/j.biopsych.2006.04.007 |
| Journal | Biological Psychiatry |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
