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Numb has distinct function in lung adenocarcinoma and squamous cell carcinoma
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kikuchi, Hajime Sakakibara-Konishi, Jun Furuta, Megumi Kikuchi, Eiki Kikuchi, Junko Oizumi, Satoshi Hida, Yasuhiro Kaga, Kichizo Kinoshita, Ichiro Dosaka-akita, Hirotoshi Nishimura, Masaharu |
| Copyright Year | 2018 |
| Abstract | Some reports suggest that Numb is a potential tumor suppressor. However, its role in non-small cell lung cancer remains unclear. Non-small cell lung cancer comprises two major histological subtypes, adenocarcinoma and squamous cell carcinoma. To investigate the role of Numb in tumorigenesis of lung adenocarcinoma and squamous cell carcinoma, we firstly performed loss-of-function and gain-of-function assays. Moreover, Numb expression was investigated in surgically resected lung adenocarcinoma and squamous cell carcinoma tissues by immunohistochemistry and correlations with prognosis were analyzed. Numb suppressed the proliferation, migration, and invasion of adenocarcinoma cells and inhibited Notch signaling and epithelial-mesenchymal transition in vitro. Numb overexpression also inhibited subcutaneous adenocarcinoma tumor growth. In contrast, Numb promoted the proliferation, migration, and invasion of squamous cell carcinoma cells, but did not induce any consistent changes in Notch signaling. High Numb expression was associated with favorable prognosis in patients with lung adenocarcinoma, but not in those with squamous cell carcinoma. Collectively, our data demonstrate that Numb plays distinct roles in lung adenocarcinoma and squamous cell carcinoma. In lung adenocarcinoma, Numb impairs tumor growth and inhibits the Notch pathway and epithelial-mesenchymal transition, whereas in lung squamous cell carcinoma it may promote proliferation. |
| Starting Page | 29379 |
| Ending Page | 29391 |
| Page Count | 13 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.oncotarget.com/index.php?journal=oncotarget&op=download&page=article&path%5B%5D=25585&path%5B%5D=80082 |
| PubMed reference number | 6047666 |
| Alternate Webpage(s) | https://doi.org/10.18632/oncotarget.25585 |
| DOI | 10.18632/oncotarget.25585 |
| Journal | Oncotarget |
| Volume Number | 9 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adenocarcinoma of lung (disorder) Biomarkers, Tumor Body tissue Carcinogenesis NUMB gene Neoplasms Nephroblastoma Non-Small Cell Lung Carcinoma Operative Surgical Procedures Patients Small cell carcinoma of lung Squamous Epithelial Cells Squamous cell carcinoma Squamous cell lung carcinoma Subtype (attribute) epithelial to mesenchymal transition |
| Content Type | Text |
| Resource Type | Article |
