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20-nm-sized mesoporous silica nanoparticles with porphyrin photosensitizers for in vitro photodynamic therapy
| Content Provider | Semantic Scholar |
|---|---|
| Author | Jimenez, Chiara Mauriello Rubio, Yolanda Galàn Saunier, Valentin Warther, David Stojanovic, Vanja Raehm, Laurence Frochot, Céline Arnoux, Philippe Garcia, Marcel Morère, Alain Bettache, Nadir Maynadier, Marie Maillard, Philippe Gary-Bobo, Magali Durand, Jean-Olivier |
| Copyright Year | 2016 |
| Abstract | We report the synthesis of 20-nm-sized mesoporous silica nanoparticles encapsulating three different porphyrin photosensitizers (PS). Synthesized by the sol–gel method, in the presence of cetyltrimethylammonium bromide surfactant and tetraorthosilicate as silica source, we developed those nanoparticles with the aim of treating cancer cells using photodynamic therapy. The colloidal stability, due to the PEG-silane chain grafted on the surface, was demonstrated at 37 °C in cell culture medium. Then, nanoparticles were functionalized by silylated squarate mannose and used in MCF-7 breast cancer cells for one-photon therapy. Promising results were obtained after 5 h of incubation.Graphical Abstract |
| Starting Page | 447 |
| Ending Page | 456 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/s10971-016-3991-6 |
| Volume Number | 79 |
| Alternate Webpage(s) | https://hal.univ-lorraine.fr/hal-01569372/document |
| Alternate Webpage(s) | https://hal.univ-lorraine.fr/hal-01569372/file/09%20Mauriello%20et%20al.pdf |
| Alternate Webpage(s) | https://doi.org/10.1007/s10971-016-3991-6 |
| Journal | Journal of Sol-Gel Science and Technology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
