NDLI: Functional polymorphism in the serotonin transporter promoter at the SLC6A4 locus and mood disorders

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Functional polymorphism in the serotonin transporter promoter at the SLC6A4 locus and mood disorders

Content Provider	Semantic Scholar
Author	Ohara, Koichi Nagai, Miho Tsukamoto, Toshio Tani, Kunihiko Ohara, Kenshiro
Copyright Year	1998
Abstract	BACKGROUND Heils et al found a functional polymorphism in the transcriptional control region upstream of the serotonin transporter gene at the SLC6A4 locus. The transcriptional promoter activity of the short (s) form was less than twice that of the long (l) form of the serotonin transporter promoter gene. In addition, they found individuals with the s form with associated neurotic characteristics (e.g., anxiety, anger, hostility, and depression). The purpose of this study was to determine whether or not there is an association between this functional polymorphism and mood disorders. METHODS The l/s polymorphism was studied in 80 patients with mood disorders and 92 control subjects. RESULTS There was statistically no difference between mood disorders and healthy controls in either the genotype or the allele frequency. There was statistically no difference between the genotype and subdiagnosis, family history, single/recurrent episodes of depressive disorders, suicide attempts, or the mean age of onset. CONCLUSIONS Our results suggest there is no association between the l/s polymorphism of the serotonin transporter gene and mood disorders.
Starting Page	550
Ending Page	554
Page Count	5
File Format	PDF HTM / HTML
PubMed reference number	9787878
Journal	Medline
Volume Number	44
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0006322398001127
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0006322398001127?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/S0006-3223%2898%2900112-7
Journal	Biological Psychiatry
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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