Nitric oxide synthase inhibitor aminoguanidine potentiates iminodipropionitrile-induced neurotoxicity in rats

Content Provider	Semantic Scholar
Author	Tariq, Mohammad Khan, Haseeb Ahmad Deeb, Saleh Al Moutaery, Khalaf R. Al
Copyright Year	1999
Abstract	This investigation was undertaken to study the effect of nitric oxide synthase inhibitor, aminoguanidine on iminodipropionitrile (IDPN)-induced neurobehavioral and vestibular toxicity in rats. The dyskinetic syndrome was produced in male Wistar rats by i.p. injections of IDPN (100 mg/kg) for 6 days. Aminoguanidine was administered orally in the doses of 50, 150 and 300 mg/kg, 60 min before IDPN in three different groups. Control rats received vehicle only, whereas another group was treated with 300 mg/kg of aminoguanidine alone (without IDPN). Our results showed that aminoguanidine significantly and dose dependently exacerbated the incidence and intensity of IDPN-induced dyskinetic head movements. Aminoguanidine potentiated IDPN-induced loss of air righting reflex. The histopathological examination of inner ear showed aggravation of IDPN-induced degeneration of sensory hair cells in the crista ampullaris by aminoguanidine. These results suggest the role of nitric oxide in IDPN-induced neurobehavioral and vestibular toxicity.
Starting Page	49
Ending Page	52
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1016/S0304-3940(99)00789-2
PubMed reference number	10586972
Journal	Medline
Volume Number	276
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0304394099007892
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0304394099007892?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://faculty.ksu.edu.sa/haseeb/Toxicology%20%20Environmental%20Health/Nitric%20oxide%20synthase%20inhibitor.pdf
Alternate Webpage(s)	https://doi.org/10.1016/S0304-3940%2899%2900789-2
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article