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Limited STIMULATION OF DENDRITOGENESIS IN THE EPIDERMAL MELANOCYTES OF NEWBORN MICE BY MELANOCYTE-STIMULATING HORMONE
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hirobe, Tomohisa |
| Copyright Year | 2005 |
| Abstract | The number of dendrites and the total length of dendrites in the epidermal melanocytes positive for the dopa reaction were shown to increase when newborn mice were injected with a-MSH or DBc-AMP. Moreover, both indices of the degree of dendritogenesis increased when skin explants of newborn mice were cultured in medium containing a-MSH or DBcAMP. Electron-microscopic observation showed that the number of melanosomes was also increased by a-MSH treatment. Many mature melanosomes were observed in the dendrites of the epidermal melanocytes of a-MSH-injected mice. Highly dendritic melanocytes seem to be the cells stimulated by MSH to form melanosomes and translocate them to dendrites. Dendritogenesis stimulated by the hormone was suppressed by actinomycin D or cycloheximide, suggesting that the dendritogenesis in the epidermal melanocytes requires de novo transcription and translation. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://jcs.biologists.org/content/joces/33/1/371.full.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
