NDLI: Effects of quetiapine on the brain-derived neurotrophic factor expression in the hippocampus and neocortex of rats

Please wait, while we are loading the content...

Effects of quetiapine on the brain-derived neurotrophic factor expression in the hippocampus and neocortex of rats

Content Provider	Semantic Scholar
Author	Park, Sung-Woo Lee, Sunkyung Kim, Jae-Min Yoon, Jin-Sang Kim, Young-Hoon
Copyright Year	2006
Abstract	The effects of antipsychotics on the brain-derived neurotrophic factor (BDNF) expression have been controversial. This study aimed to investigate the effects of chronic quetiapine administration on the BDNF mRNA expression in hippocampus and neocortex of rats with or without immobilization stress. The chronic administration (21 days) of quetiapine (10 mg/kg) significantly attenuated the decreased BDNF mRNA expression in the both hippocampal and cortical regions of rats caused by immobilization stress, and significantly increased the BDNF mRNA expression in the dentate gyrus of rats even without the immobilization stress. These results could add some theoretical bases to explain why quetiapine may improve cognitive symptoms of schizophrenia by stimulating BDNF mRNA expression.
Starting Page	25
Ending Page	29
Page Count	5
File Format	PDF HTM / HTML
DOI	10.1016/j.neulet.2006.03.028
PubMed reference number	16713676
Journal	Medline
Volume Number	402
Alternate Webpage(s)	http://www.mentalhealth.kr/publication/files/1@6.%20Quetiapine-BDNF(2006).pdf
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0304394006002862
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0304394006002862?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/j.neulet.2006.03.028
Journal	Neuroscience Letters
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in