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Peripheral blood BDNF-TrkB signaling in first-episode, drug-free patients with major depressive disorder and schizophrenia
| Content Provider | Semantic Scholar |
|---|---|
| Author | Chen, Lei Li, Xue-Song Zheng, Guang-En Xie, Guojun Cheng, Yong |
| Copyright Year | 2020 |
| Abstract | Brain-derived neurotrophic factor (BDNF) has been implicated in the pathogenesis of psychiatric disorders, and studies have shown BDNF aberrations in major psychiatric diseases including schizophrenia (SCZ) and major depressive disorder (MDD). However, data from clinical studies were inconsistent. In this study, we recruited 34 patients with MDD, 77 patients with SCZ and 65 healthy control (HC) subjects to clarify the circulating BDNF levels in MDD and SCZ patients, and to assess whether serum BDNF levels were associated with the disease severity. Our results showed that serum BDNF levels were significantly decreased in the patients with SCZ (Mean difference = -4.517, 95%CI of difference = -7.854 to -1.180, p < 0.01) and MDD (Mean difference = -5.699, 95%CI of difference = -9.892 to -1.506, p < 0.01) when compared with HC subjects. Sub-group analyses suggested that BDNF levels were significantly reduced in the female SCZ (Mean difference = -5.700, 95%CI of difference = -10.21 to -1.189, p < 0.01) and MDD (Mean difference = -5.840, 95%CI of difference = -10.66 to -1.019, p < 0.05) patients, but not in male patients. Further analyses indicated that serum BDNF levels were not correlated with disease severity of MDD and SCZ. In addition, the transcriptional expression of TrkB was significantly down-regulated in the blood of MDD patients, but not in SCZ patients. However, there was no significant correlation between BDNF concentrations and TrkB mRNA levels. Taken together, our results revealed differential changes of BDNF-TrkB signaling in MDD and SCZ patients, therefore contributed to a better understanding of MDD and SCZ pathophysiology. |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.neulet.2019.134618 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0304394019307219 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0304394019307219?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 31711978 |
| Alternate Webpage(s) | https://doi.org/10.1016/j.neulet.2019.134618 |
| Journal | Medline |
| Volume Number | 714 |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
