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Theoretical Research on Dynamics of the Genetic Toggle Switch
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ushikubo, Tomohiro Inoue, Wataru Yoda, Mitsumasa Sasai, Masaki |
| Copyright Year | 2007 |
| Abstract | The toggle switch is a network composed of two genes in which proteins synthesized by one gene represses expression of the other gene (fig.1a). Chemical reactions for each gene are modeled by four processes (fig.1b). First process is the protein production: The protein production rate is g in the repressor-unbound state, and 0 in the repressor-bound state. The synthesized protein acts as a repressor on another gene. Second is the protein degradation with the degradation rate, k. Third is the protein-binding to DNA with the binding rate, hni(ni−1), where ni is the number of the repressor proteins synthesized from the ith gene with i = 1 or 2. Fourth is the protein dissociation from DNA with the dissociation rate, f. In this study we use the value f/h=1000. When the gene switch fluctuates on and off, frequency of the DNA status change is measured by ω= f/k and the representative number of proteins is Xad= g/2k. We calculate the master equation by using the Monte Carlo (MC) simulation with the Gillespie algorithm[2]. |
| Starting Page | 289 |
| Ending Page | 292 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.jsbi.org/pdfs/journal1/GIW05/GIW05P121.pdf |
| Alternate Webpage(s) | https://doi.org/10.1007/978-3-540-46375-7_43 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
