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Evidence against an increase in capillary permeability in subjects exposed to high altitude.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kleger, Gian Reto Bärtsch, Peter Vock, Peter Heilig, Bernhard Ballmer, Peter Ernst |
| Copyright Year | 1996 |
| Abstract | A potential pathogenetic cofactor for the development of acute mountain sickness and high-altitude pulmonary edema is an increase in capillary permeability, which could occur as a result of an inflammatory reaction and/or free radical-mediated injury to the lung. We measured the systemic albumin escape by intravenously injecting 5 muCi of 125I-labeled albumin and the plasma concentrations of cytokines, F2-isoprostanes (products of lipid peroxidation), and acute-phase proteins in 24 subjects exposed to 4,559 m. Ten subjects developed acute mountain sickness, and four subjects developed high-altitude pulmonary edema. The transcapillary escape rate of albumin was 6.9 +/- 2.0%/h (SD) at low (550 m) and 6.3 +/- 1.9%/h at high (4,559 m) altitude (P = 0.23; n = 24). The subjects with high-altitude pulmonary edema had a modest but insignificant increase in the transcapillary escape rate of albumin (4.6 +/- 1.9%/h at low vs. 5.7 +/- 1.9%/h at high altitude; P = 0.42; n = 4). Plasma concentrations of fibrinogen, alpha 1-acid glycoprotein, C-reactive protein, and interleukin-6 were unchanged in the early phases and significantly increased by the end of the observation period in the subjects with high-altitude pulmonary edema, whereas tumor necrosis factor-alpha and F2-isoprostanes did not change at all. This suggests that the inflammatory reaction was rather a consequence than a causative factor of high-altitude pulmonary edema. In summary, these data argue against a dominant role for increased systemic capillary permeability in the development of acute mountain sickness and high-altitude pulmonary edema. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://jap.physiology.org/content/jap/81/5/1917.full.pdf |
| PubMed reference number | 8941510v1 |
| Volume Number | 81 |
| Issue Number | 5 |
| Journal | Journal of applied physiology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Altitude Sickness C-reactive protein Capillary Permeability F2-Isoprostanes Free Radicals Illness (finding) Leukemia, Myelocytic, Acute Lipid Peroxidation Physiological Sexual Disorders Pulmonary Edema Structure of parenchyma of lung Tracer Tumor Necrosis Factors acute mountain sickness chemical cofactor |
| Content Type | Text |
| Resource Type | Article |
