NDLI: La sobreexpresión del gen de enzima convertidora de angiotensina homóloga (ECA2) revierte la hipertensión arterial y el remodelado cardíaco experimental

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La sobreexpresión del gen de enzima convertidora de angiotensina homóloga (ECA2) revierte la hipertensión arterial y el remodelado cardíaco experimental

Content Provider	Semantic Scholar
Author	Ramos, Elizabeth Herrera, Alejandro García Moya, Jackeline Apablaza, Felipe Godoy, Iván Jalil, Jorge E. Lavandero, Sergio Chiong, Mario Ocaranza, María Paz
Copyright Year	2010
Abstract	Resumen: Antecedentes: La sobreexpresion genica de la en-zima convertidora de angiotensina I homologa (ECA2) se asocia con prevencion de la hipertrofia y fibrosis car-diaca dependiente de angiotensina (Ang) II. Sin embargo se desconoce si su sobreexpresion reduce la hipertension arterial (HTA) y revierte el consecuente remodelado mio-cardico (RM) dependiente de Ang II. Objetivo: Determinar si la sobreexpresion adenoviral (Ad) del gen de la ECA2 en el miocardio disminuye la HTA y RM experimental en ratas con niveles genetica-mente determinados de ECA y Ang II . Metodos: Ratas homocigotas normotensas Lewis (LL) y Brown Borway (BN), con menores y mayores niveles circulantes de ECA y Ang II, respectivamente, se hicieron hipertensas por el procedimiento Goldblatt (GB). Como controles se usaron ratas seudo-operadas (sham). A la semana 5 post cirugia y con HTA establecida ≥ 140 mmHg, las ratas se randomizaron a inyeccion intra-miocardica con un AdECA2 o Ad proteina fluorescente verde (GFP) como controles de infeccion. A la semana post infeccion adenoviral, los ratas se sacrificaron y se determinaron peso corporal (PC, g), masa cardiaca (MC, mg), presion arterial sistolica (PAS, mmHg), area (AC, um2) y perimetro (PERC, um) de cardiomiocitos y conte-nido de colageno (%) miocardico (CM), sub-endocardico (CS) y total (CT).
Starting Page	334
Ending Page	341
Page Count	8
File Format	PDF HTM / HTML
DOI	10.4067/S0718-85602010000300008
Volume Number	29
Alternate Webpage(s)	https://scielo.conicyt.cl/pdf/rchcardiol/v29n3/art08.pdf
Alternate Webpage(s)	https://doi.org/10.4067/S0718-85602010000300008
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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