Loading...
Please wait, while we are loading the content...
Similar Documents
Exercise Training Prevents Cardiovascular Derangements Induced by Fructose Overload in Developing Rats
| Content Provider | Semantic Scholar |
|---|---|
| Author | Farah, Daniela Nunes, Jonas Constancio Sartori, Michelle Dias, Danielle Da Silva Sirvente, Raquel De Assis Silva, Maikon Barbosa Da Fiorino, Patrícia Morris, Mariana Llesuy, Susana Francisca Farah, V. M. A. Irigoyen, Maria-Cláudia Angelis, Kátia De |
| Copyright Year | 2016 |
| Abstract | The risks of chronic diseases associated with the increasing consumption of fructose-laden foods are amplified by the lack of regular physical activity and have become a serious public health issue worldwide. Moreover, childhood eating habits are strongly related to metabolic syndrome in adults. Thus, we aimed to investigate the preventive role of exercise training undertaken concurrently with a high fructose diet on cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in male rats after weaning. Male Wistar rats were divided into 4 groups (n = 8/group): Sedentary control (SC), Trained control (TC), Sedentary Fructose (SF) and Trained Fructose (TF). Training was performed on a treadmill (8 weeks, 40-60% of maximum exercise test). Evaluations of cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in plasma and in left ventricle (LV) were performed. Chronic fructose overload induced glucose intolerance and an increase in white adipose tissue (WAT) weight, in myocardial performance index (MPI) (SF:0.42±0.04 vs. SC:0.24±0.05) and in arterial pressure (SF:122±3 vs. SC:113±1 mmHg) associated with increased cardiac and vascular sympathetic modulation. Fructose also induced unfavorable changes in oxidative stress profile (plasmatic protein oxidation- SF:3.30±0.09 vs. SC:1.45±0.08 nmol/mg prot; and LV total antioxidant capacity (TRAP)- SF: 2.5±0.5 vs. SC:12.7±1.7 uM trolox). The TF group showed reduced WAT, glucose intolerance, MPI (0.35±0.04), arterial pressure (118±2mmHg), sympathetic modulation, plasmatic protein oxidation and increased TRAP when compared to SF group. Therefore, our findings indicate that cardiometabolic dysfunctions induced by fructose overload early in life may be prevented by moderate aerobic exercise training. |
| File Format | PDF HTM / HTML |
| PubMed reference number | 27930685 |
| Journal | Medline |
| Volume Number | 11 |
| Alternate Webpage(s) | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0167291&type=printable |
| Alternate Webpage(s) | https://doi.org/10.1371/journal.pone.0167291 |
| Journal | PloS one |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
