NDLI: Optimization of extraction process for extract yields, total flavonoid content, radical scavenging activity and cytotoxicity of Curcuma aeruginosa RoxB. rhizome

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Optimization of extraction process for extract yields, total flavonoid content, radical scavenging activity and cytotoxicity of Curcuma aeruginosa RoxB. rhizome

Content Provider	Semantic Scholar
Author	Qomaliyah, Eka Nurul Artika, I. Made Nurcholis, Waras
Copyright Year	2019
Abstract	The rhizome of Curcuma aeruginosa RoxB. (RCA) Is used traditionally for several diseases. The lavonoid compounds contained in the RCA that responsible for biological activities. In this study, ethanol, water, and acetone had been used as solvent extraction of RCA and applied the simplex-centroid design to optimize the extraction process. The radical scavenging activity and total lavonoid content were investigated using in vitro assays, while cytotoxicity was evaluated by brine shrimp lethality test. ANOVA suggested a linear model for all responses. The ethanol: acetone extract had the highest extract yield with a value of 25.15%, and this result showed no signi icant with acetone extract at p < 0.05 (22.86%). The ethanol extracts con irmed the higher degree of total lavonoid content and cytotoxicity with a value of 17.97 mg QE/g and 140 μg/ml, respectively. The ethanol: water extract, ethanol extract, andwater extract (IC50, 100-500 μg/ml) showedmoderate radical scavenging activity comparedwith ascorbic acid (IC50, 7.19μg/ml). Regarding the correlation analysis, the negative correlation was weakly observed between lavonoid content and IC50 of free radical scavenging activity, which indicates that the lavonoid in RCA contributes not signi icantly to the antioxidant activity. Introductory studies on the extraction process of the advanced lavonoid extracts exhibited a scavenging and cytotoxic effect of the ethanol extract on C. aeruginosa rhizome.
Starting Page	1650
Ending Page	1659
Page Count	10
File Format	PDF HTM / HTML
DOI	10.26452/ijrps.v10i3.1331
Volume Number	10
Alternate Webpage(s)	https://pharmascope.org/index.php/ijrps/article/download/1331/1266
Alternate Webpage(s)	https://doi.org/10.26452/ijrps.v10i3.1331
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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