NDLI: Regeneration of halved embryonic lower first mouse molars: correlation with the distribution pattern of non dividing IDE cells, the putative organizers of morphogenetic units, the cusps.

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Regeneration of halved embryonic lower first mouse molars: correlation with the distribution pattern of non dividing IDE cells, the putative organizers of morphogenetic units, the cusps.

Content Provider	Semantic Scholar
Author	Coin, R. Schmitt, Rolf Lesot, Hervé Vonesch, Jean Luc Ruch, Jean Victor
Copyright Year	2000
Abstract	Recently we demonstrated that non-cycling, cap-stage, mouse molar inner dental epithelial (IDE) cells corresponding to the primary enamel knot (EK) area underwent a coordinated temporo-spatial patterning leading to their patchy irregular segregation at the tips of the forming cusps. These non-cycling cells were suggested to perhaps represent the organizers of the morphogenetic units (OMU), the cusps. The present study has analyzed the regenerative capacity of halved cap-stage first lower mouse molars through three dimensional (3D) reconstructions. Partial regeneration of the anterior half and possible complete regeneration of the posterior half were documented. Using BrdU (5-bromo-2'-deoxyuridine) labeling and 3D reconstructions of the IDE, we have correlated the patterns of cusp regeneration with the distribution of BrdU negative IDE cells. These data support a morphogenetic role for the non-cycling IDE cells.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.ijdb.ehu.es/web/descarga/paper/10853825
PubMed reference number	10853825v1
Volume Number	44
Issue Number	3
Journal	The International journal of developmental biology
Language	English
Access Restriction	Open
Subject Keyword	Bromodeoxyuridine Dental Enamel Hypoplasia IDE gene Leuciscus idus Molar tooth Natural regeneration Sodium monofluorophosphate 0.0076 MG/MG Toothpaste
Content Type	Text
Resource Type	Article

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