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Interobserver agreement of Gleason score and modified Gleason score in needle biopsy and in surgical specimen of prostate cancer.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Veloso, Sérgio G. Lima, Mário Ferreira Salles, Paulo Guilherme De Oliveira Berenstein, Cynthia Koeppel Bambirra, Eduardo Alves |
| Copyright Year | 2007 |
| Abstract | INTRODUCTION Gleason score, which has a high interobserver variability, is used to classify prostate cancer. The most recent consensus valued the tertiary Gleason pattern and recommended its use in the final score of needle biopsies (modified Gleason score). This pattern is considered to be of high prognostic value in surgical specimens. This study emphasized the evaluation of the modified score agreement in needle biopsies and in surgical specimen, as well as the interobserver variability of this score. MATERIALS AND METHODS Three pathologists evaluated the slides of needle biopsies and surgical specimens of 110 patients, reporting primary, secondary and tertiary Gleason patterns and after that, traditional and modified Gleason scores were calculated. Kappa test (K) assessed the interobserver agreement and the agreement between the traditional and modified scores of the biopsy and of the surgical specimen. RESULTS Interobserver agreement in the biopsy was K = 0.36 and K = 0.35, and in the surgical specimen it was K = 0.46 and K = 0.36, for the traditional and modified scores, respectively. The tertiary Gleason grade was found in 8%, 0% and 2% of the biopsies and in 8%, 0% and 13% of the surgical specimens, according to observers 1, 2 and 3, respectively. When evaluating the agreement of the traditional and modified Gleason scores in needle biopsy with both scores of the surgical specimen, a similar agreement was found through Kappa. CONCLUSION Contrary to what was expected, the modified Gleason score was not superior in the agreement between the biopsy score and the specimen, or in interobserver reproducibility, in this study. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://seed.ucsd.edu/mediawiki/images/3/3a/Reproducibility2.pdf |
| PubMed reference number | 17980061v1 |
| Volume Number | 33 |
| Issue Number | 5 |
| Journal | International braz j urol : official journal of the Brazilian Society of Urology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | CDISC SEND Biospecimens Terminology Gleason Grading System Needle biopsy procedure Patients Prostatic Neoplasms Slide (glass microscope) Specimen Tertiary Gleason Pattern high-grade childhood cerebral astrocytoma observers |
| Content Type | Text |
| Resource Type | Article |
