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Cis-regulatory RNA elements that regulate specialized ribosome activity.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Xue, Shifeng Barna, Mária |
| Copyright Year | 2015 |
| Abstract | Recent evidence has shown that the ribosome itself can play a highly regulatory role in the specialized translation of specific subpools of mRNAs, in particular at the level of ribosomal proteins (RP). However, the mechanism(s) by which this selection takes place has remained poorly understood. In our recent study, we discovered a combination of unique RNA elements in the 5'UTRs of mRNAs that allows for such control by the ribosome. These mRNAs contain a Translation Inhibitory Element (TIE) that inhibits general cap-dependent translation, and an Internal Ribosome Entry Site (IRES) that relies on a specific RP for activation. The unique combination of an inhibitor of general translation and an activator of specialized translation is key to ribosome-mediated control of gene expression. Here we discuss how these RNA regulatory elements provide a new level of control to protein expression and their implications for gene expression, organismal development and evolution. |
| Starting Page | 512 |
| Ending Page | 515 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://barnalab.stanford.edu/resources/ShifengRNAbiology.pdf |
| PubMed reference number | 26327194v1 |
| Alternate Webpage(s) | https://doi.org/10.1080/15476286.2015.1085149 |
| DOI | 10.1080/15476286.2015.1085149 |
| Journal | RNA biology |
| Volume Number | 12 |
| Issue Number | 10 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | 5' Untranslated Regions Gene Expression Internal Ribosome Entry Sites Organism RNA Ribosomal Proteins Ribosomes protein expression |
| Content Type | Text |
| Resource Type | Article |
