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Diagnostic and prognostic factors for patients with primary pulmonary non-Hodgkin's lymphoma: A 16-year single-center retrospective study.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Qian, Jiang Luo, Dong-Lan Zhang, Jine Li, Wenyu Gao, Xing-Lin Fang, Xiang-Feng Deng, Jun-Liang Li, Qiong Wu, Jian Guo |
| Copyright Year | 2019 |
| Abstract | Primary pulmonary non-Hodgkin's lymphoma (PP-NHL) is a rare entity with non-specific symptoms and radiographic findings, as well as a difficult preoperative diagnosis. A limited number of studies have described PP-NHL in Chinese patients. The goal of the present study was to improve early diagnosis by examining prognostic factors in patients with PP-NHL. Therefore, a total of 29 patients with PP-NHL were included in the study between January 2001 and June 2017, including 14 with aggressive-type and 15 with indolent-type lymphomas (10 male, 19 female; median age, 50.3 years; range, 19-87 years). Pulmonary nodules and masses (55.2%) were the most common radiographic features. The diagnostic yield was 80% (12/15) by endobronchial biopsy or transbronchial lung biopsy and 100% by computed tomography (CT)-guided percutaneous needle lung biopsy (11/11) or surgery (8/8). Elevated lactate dehydrogenase levels and systemic symptoms were observed considerably more often in patients with aggressive disease than in those with indolent disease. The 1-, 3- and 5-year overall survival (OS) rates were 42, 32, and 21%, respectively, for all patients, 72, 57 and 43%, respectively, for patients with indolent lymphomas, and 13, 6 and 0%, respectively, for patients with aggressive lymphomas. The median OS rate for all patients was 12.0 months; however, the OS rate for patients with aggressive lymphomas was significantly shorter compared with those with indolent lymphomas (7.1 months vs. 16.6 months; P=0.002). Aggressive vs. indolent lymphoma status was indicated to be an independent prognostic factor for poor 5-year OS rate (hazard ratio, 5.98; P=0.014). In conclusion, bronchoscopic and CT-guided percutaneous needle lung biopsies were the most useful and least invasive procedures for diagnosing PP-NHL. Furthermore, aggressive PP-NHL was highly associated with poor 5-year OS rate and a poor prognosis. |
| Starting Page | 2082 |
| Ending Page | 2090 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| DOI | 10.3892/ol.2019.10469 |
| PubMed reference number | 31423281 |
| Journal | Medline |
| Volume Number | 18 |
| Issue Number | 2 |
| Journal | Oncology letters |
| Alternate Webpage(s) | https://www.spandidos-publications.com/ol/18/2/2082/download |
| Alternate Webpage(s) | https://doi.org/10.3892/ol.2019.10469 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
