Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement.

Content Provider	Semantic Scholar
Author	Ntziachristos, Vasilis Yodh, Arjun G. Schnall, Mitchell Chance, Britton
Copyright Year	2000
Abstract	We present quantitative optical images of human breast in vivo. The images were obtained by using near-infrared diffuse optical tomography (DOT) after the administration of indocyanine green (ICG) for contrast enhancement. The optical examination was performed concurrently with a magnetic resonance imaging (MRI) exam on patients scheduled for excisional biopsy or surgery so that accurate image coregistration and histopathological information of the suspicious lesions was available. The ICG-enhanced optical images coregistered accurately with Gadolinium-enhanced magnetic resonance images validating the ability of DOT to image breast tissue. In contrast to simple transillumination, we found that DOT provides for localization and quantification of exogenous tissue chromophore concentrations. Additionally our use of ICG, an albumin bound absorbing dye in plasma, demonstrates the potential to differentiate disease based on the quantified enhancement of suspicious lesions.
File Format	PDF HTM / HTML
PubMed reference number	10706610
Journal	Medline
Volume Number	97
Issue Number	6
Alternate Webpage(s)	https://cpb-us-w2.wpmucdn.com/web.sas.upenn.edu/dist/b/502/files/2019/11/VNtziachristos2000PNASv97i6.pdf
Alternate Webpage(s)	http://light.ece.illinois.edu/ECE564/Ntziachristos-2000-Concurrent%20MRI%20and%20d.pdf
Alternate Webpage(s)	http://www.lrsm.upenn.edu/pmi/papers/AGYgroup/VasilisNtziachristos/VNtziachristos2000PNASv97i6.pdf
Alternate Webpage(s)	https://doi.org/10.1073/pnas.040570597
Journal	Proceedings of the National Academy of Sciences of the United States of America
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article