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Traditional Uighur Medicine Karapxa decoction, inhibits liver xanthine oxidase and reduces serum uric acid concentrations in hyperuricemic mice and scavenges free radicals in vitro
| Content Provider | Semantic Scholar |
|---|---|
| Author | Amat, Nurmuhammat Umar, Anwar Hoxur, Parida Anaydulla, Mihrigul Imam, Guzalnur Aziz, Ranagul Upur, Halmurat Kijjoa, Anake Moore, Nicholas |
| Copyright Year | 2015 |
| Abstract | BackgroundKarapxa decoction (KD) is a Traditional Uighur Medicine used for hepatitis, cholecystitis, gastralgia, oedema, gout and arthralgia. Because of its purported effect in gout, its effects were tested in hyperuricemic mice models induced by yeast extract paste or potassium oxonate, as well as its capacity to scavenge free radicals in vitro.MethodsHyperuricemia was induced in mice by yeast extract paste or potassium oxonate. KD was given orally for 14 days at 200, 400 and 800 mg/kg/day, with Allopurinol 10 mg/kg/day as positive control. Serum uric acid (UA), and liver xanthine oxidase activity (XO) were measured. Scavenging activity of KD on 1, 1-diphenyl-2-picrylhydrazyl radicals (DPP•), nitric oxide (•NO), superoxide (O2•-), efficiency against lipid peroxidation, and XO inhibition were determined in vitro.ResultsKD inhibited liver XO activity and reduced serum uric acid in hyperuricemic mice. KD also showed noticeable antioxidant activity, scavenging free radicals (DPP•, •NO and O2•-). It was effective against lipid peroxidation and inhibited XO in vitro.ConclusionsThis study supports the traditional use of Karapxa decoction to treat hyperuricemia and gout. |
| File Format | PDF HTM / HTML |
| PubMed reference number | 25906842 |
| Journal | Medline |
| Volume Number | 15 |
| Alternate Webpage(s) | http://old.biomedcentral.com/content/pdf/s12906-015-0644-1.pdf |
| Alternate Webpage(s) | http://bmccomplementalternmed.biomedcentral.com/track/pdf/10.1186/s12906-015-0644-1?site=bmccomplementalternmed.biomedcentral.com |
| Alternate Webpage(s) | https://doi.org/10.1186/s12906-015-0644-1 |
| Journal | BMC Complementary and Alternative Medicine |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
