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Sildenafil e inhibidores de fosfodiesterasa en hipertensión pulmonar
| Content Provider | Semantic Scholar |
|---|---|
| Author | Romero, María Jesús Cerda, Ricardo Campos Blanhir, Jaime Eduardo Morales |
| Copyright Year | 2006 |
| Abstract | Pulmonary hypertension (PH) is a pathology of pulmonary circulation. Its prototype, idiopathic pulmonary hypertension (IPAH), is model of investigations directed to early diagnosis and treatment. The vascular pulmonary endothelium has a predominant role in the disease, it different changes modify the pulmonary vascular tone, specifically decreased in production or response to nitric oxide. Treatment of pulmonary hypertension, is directed to decrease pulmonary pressure and vascular pulmonary resistance, increase survival and modify quality of life. Patients with response in the vascular pulmonary reactivity test during right side cardiac catheterism, long-term treatment with calcium channel antagonist drugs are effective in 30% of the cases. In the clinical spectrum, the high percent of patients without response during the test begins research of other candidates. Different drugs with vascular properties, like nitric oxide, prostaciclin analogs (ej. Epoprostenol, iloprost), and endothelin 1 inhibitors (bosentan) showed important results. Recently begins the phosphodiesterase 5 inhibitors evaluation because of their effects on pulmonary vascular response. Sildenafil, vardenafil and tadalafil are effective in the treatment of erectile dysfunction; they have pulmonary vasodilatatory effects by increasing nitric oxide levels and inhibition of endothelial phosphodiesterase 5. Long-term treatment with sildenafil in IPAH or PH associated to collagen vascular disease, or chronic thromboembolic disease showed favorable results in quality of life and survival. The effectiveness of the phosphodiesterase 5 inhibitors in different types of PH is under investigation. |
| Starting Page | 186 |
| Ending Page | 200 |
| Page Count | 15 |
| File Format | PDF HTM / HTML |
| Volume Number | 65 |
| Alternate Webpage(s) | http://www.medigraphic.com/pdfs/neumo/nt-2006/nt064f.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
