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[Recurrence of chronic active Epstein-Barr virus infection presenting with myelopathy after umbilical cord blood transplantation].
| Content Provider | Semantic Scholar |
|---|---|
| Author | Watanabe, Shohei Okada, Masaya Tokugawa, Tazuko Sawada, Akihiro Ogawa, Hiroyasu Yoshikawa, Hiroo |
| Copyright Year | 2014 |
| Abstract | A 38-year-old man was admitted to our hospital with neck pain, dysesthesia of both hands, and weakness of the left upper limb. He had been diagnosed with a chronic active Epstein-Barr virus infection (CAEBV) at the age of 34 and had undergone umbilical cord blood transplantation at the age of 37. MRI of the spinal cord revealed an intramedullary hyperintense lesion on Tâ‚‚-weighted images with gadolinium enhancement. Because his laboratory tests revealed proliferation of CD19(+) lymphocytes in the peripheral blood, and EBV DNA was detected in both peripheral blood and CSF, he was diagnosed as having post-transplant EBV associated lymphoproliferative disease. However, chemotherapy did not alleviate his symptoms. At a later time, quantitative chimerism analysis of his CSF showed a higher proportion of lymphocytes that had originated from the recipient. Finally, he was diagnosed as having a recurrence of CAEBV in the central nervous system, and his symptoms were restored by intrathecal chemotherapy (methotrexate, cytosine arabinoside, and prednisolone). Quantitative chimerism analysis of CSF was useful for diagnosing the recurrence of CAEBV in the central nervous system. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.jstage.jst.go.jp/article/clinicalneurol/54/10/54_809/_pdf |
| PubMed reference number | 25342015v1 |
| Volume Number | 54 |
| Issue Number | 10 |
| Journal | Rinsho shinkeigaku = Clinical neurology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | CNS disorder Chimerism Chronic Lymphocytic Leukemia Cytarabine Cytosine Dysesthesia Epstein-Barr Virus Gadolinium Hematological Disease Hospital admission Laboratory Procedures Lymphoproliferative Disorders Methotrexate Moloney murine sarcoma virus Neck Pain Nervous system structure Recurrent Malignant Neoplasm Spinal Cord Diseases Spinal Cord Neoplasms Umbilical cord structure Umbilicus (Anatomy) Upper Extremity intrathecal chemotherapy peripheral blood prednisolone umbilical cord blood transplantation |
| Content Type | Text |
| Resource Type | Article |
