NDLI: Rapid intraoperative parathyroid hormone assay in the surgical management of hyperparathyroidism.

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Rapid intraoperative parathyroid hormone assay in the surgical management of hyperparathyroidism.

Content Provider	Semantic Scholar
Author	Nelson, Craig M. Victor, Noel S.
Copyright Year	2007
Abstract	CONTEXT Historically, successful surgical management of primary hyperparathyroidism has required bilateral exploration of the neck. By confirming complete removal of hypersecreting tissue, an intraoperative parathyroid hormone (IO-PTH) assay allows use of a more limited procedure. OBJECTIVE Our objective was to evaluate the utility of IO-PTH assay used in 32 parathyroid explorations versus conventional bilateral exploration used before the advent of IO-PTH assays. METHODS Minimally invasive parathyroidectomy (MIP) was used. Plasma samples were obtained at several intervals and were analyzed for IO-PTH by use of a rapid immunochemiluminescent assay (ICMA). Outcomes were assessed by univariate inferential testing, yielding one-tailed t-test results. RESULTS The study group had a mean plasma IO-PTH level decrease of 87% at ten minutes after excision. All 32 patients who underwent MIP using IO-PTH monitoring had successful surgery. At last postoperative follow-up examination, all 32 patients were normocalcemic. There were statistically significant decreases in duration of surgery, length of hospital stay, and surgery cost. CONCLUSIONS IO-PTH levels predicted the postoperative outcome for all patients studied, can provide valuable information to surgeons, and can decrease the duration of surgery and hospital stay.
Starting Page	3
Ending Page	6
Page Count	4
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.thepermanentejournal.org/files/Winter2007/rapid.pdf
PubMed reference number	21472047v1
Volume Number	11
Issue Number	1
Journal	The Permanente journal
Language	English
Access Restriction	Open
Subject Keyword	Excision Gonadorelin Hyperparathyroidism Hyperparathyroidism, Primary Immunochemiluminometric Assay Parathyroid Hormone Receptor Parathyroidectomy Patients Surgical Management Tail t test
Content Type	Text
Resource Type	Article

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